National Industrial Biotechnology Facility (NIBF) and Centre for Process Innovation (CPI)

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National Industrial Biotechnology Facility (NIBF) and Centre for Process Innovation (CPI)

The pilot manufacturing and process development services will be located in the National Industrial Biotechnology Facility (NIBF) that is an industrially focused service within the Centre for Process Innovation (CPI) at Wilton. It comprises a development laboratory and pilot-plant capabilities.

Owned and operated by CPI the NIBF is available for producing microbial proteins and enzymes and cells for biocatalysis and for biotransformations at pilot scale. Downstream chemical processing will allow recovery of low molecular weight metabolites and polymers (e.g. DNA) for non-clinical use. The facility will be developed and expanded in response to the demand of its customers.

The biotechnology facility will provide a "rapid-response" team focusing on the scale-up of enzyme preparations and/or biotransformations to make product at the kilo level.

Laboratory

Cell Bank preparation
Analytical service
Sterility/microbiology service

Fermentation

1000 litre fermenter with Control Process Analytical Technology
10 to 50 litre fermenter seed vessels

Down Stream Processing

Whole broth separation for biomass or liquor
Cell paste extraction by homogenisation
Clarification
Protein purification and immobilisation as required

Outputs and Standards

Documentation as a Technology Transfer Package for the customer to establish a commercial supply of biocatalyst or product of biocatalysis
The service provided will enable industry to scale up with confidence for the assured commercial supply of quality products
Provide Technical Transfer Packages
Provide samples of biocatalysts and biotransformed products
Supply low volumes of biocatalysts and biotransformed products
Provide training
ISO 9000 operating standards
Certified free of animal products

Location

The Centre for Process Innovation, Wilton Centre, Wilton, Redcar, TS10 4RF, UK.

Contact

Dr Chris Dowle on tel. +44 (0)1642 447 278 or email: chris.dowle@uk-cpi.com

A cGMP facility (200 litre) is planned at the Centre for Accelerated Life Sciences Commercialisation (CALSC), Annan, Dumfries and Galloway, and will be available to CoEBio3.