Enzyme Databases

The following website links are useful for mining for information (nomenclature, mechanistic, genetic and proteomic) relating to enzymology.

www. ncbi .nlm.nih.gov/ National Centre for Biotechnology information. Established in 1988 as a national resource for molecular biology information, NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information - all for the better understanding of molecular processes affecting human health and disease.

http://www.brenda.uni-koeln.de/ Brenda is the comprehensive enzyme information service. Includes data on nomenclature, mechanisms, specificity, stability, structure and isolation.

http://www.expasy.org/enzyme/ Expasy. The ENZYME section of expasy is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided

http://www.pdb.org The RCSB Protein Databank (PDB) provides a variety of tools and resources for studying the structures of biological macromolecules and their relationships to sequence, function, and disease.

http://www.biochemweb.org/enzymes.shtml Biochemweb is The Virtual Library of Biochemistry, Molecular Biology and Cell Biology. The enzyme section contains some very useful links to general enzymology sites, further enzyme databases and enzyme-specific websites.

http://www.icgeb.trieste.it/~p450srv/ The International Centre for Genetic Engineering and Biotechnology. There is an area of this site dedicated to P450-containing enzyme systems.

http://precise.bu.edu/default.aspx PRECISE (Pre dicted and C onsensus I nteraction S ites in E nzymes). A database of interactions between the amino acid residues of an enzyme and its various ligands, i.e., substrate and transition state analogues, cofactors, inhibitors, and products